Der "Brandbrief" von George Ebers (Buchrevision und Recherche)

W.W. , Freitag, 03.01.2020, 13:57 (vor 1575 Tagen) @ kerstin

Die korrigierte Version:

Dear Mr. Ebers,

since a long time I appreciate your work on MS. As example I want to quote your article in Neurology 2008: “Disability as an outcome in MS clinical trials”, where you stated:

Clinical surrogates of unremitting disability used in trials of relapsing-remitting multiple sclerosis cannot be validated. Trials have been too short or degrees of disability change too small to measure the key outcomes.

I am a German neurologist and have spent a lot of time in MS. My impression has always been that neurologists tend to cast a bad light on the natural history of MS and draw a poor picture of its prognosis. So I frequently tangled with the German MS Society.

So I was very happy that someone in our MS-forum draw my attention to your open letter you addressed to the EMA 2013. I must confess that I never heard of it before.

Particulary impressed me that someone so familiar with MS research and clinical studies could express his serious concerns so impressively. My Point is: I see huge Problems when the German MS Society recommends in its guidelines a hit-hard-and-early-strategy for newly affected,

I would therefore like to take this opportunity to ask you the following questions:

- Do you think that the "basistherapy" (this is a misleading Notion, what is used in the German MS-literatur) with betainterferons, Glatirameracetat, Fingolimod etc. has had a desirable effect on the course of MS?

- Would you agree, that more aggressive therapies such as Natalizumab or Ocrelizumab are not a promising option to treat MS?

- Is it correct to define a "benign MS" as a MS, which has 15 years after beginning an EDDS >= 3,0?

- Would you agree with SJ Pittock, who found in the Olmstedt County study that MS worsens naturally (i.e untreated) by an average of 1.0 EDSS points every 10 years?

Me and my 'combattors' in our MS-Forum would be very glad and thankful to hear of you.

Best regards,

Ich danke dir für deine Mühe.

Des weiteren fällt mir auf, dass du nicht benennst, was du über ms veröffentlicht hast, das wird ihn bestimmt interessieren.

Und deine bisherigen Konflikte kommen mir auch zu kurz.

Ich wollte das alles eigentlich nicht. Vor allem wollte ich mich nicht als jemand aufspielen, der wie ein wichtiger Verbündeter auftritt, also jemand, der zusammen mir George Ebers ein Hühnchen mit MS-Gesellschaften zu rupfen hat. Und die lächerlichen "black holes"? Wer weiß das schon? Und wen interessiert das noch?

Trotzdem herzlichen Dank!!!

Wolfgang