Hier auch noch ein paar Papers zum Thema:

Titel: Prodromal symptoms of multiple sclerosis in primary care.
Interpretation: Various clinical disturbances precede MS diagnosis by several years, supporting a prodromal phase to the disease and improving our clinical knowledge of early MS. Integrating these symptoms in the diagnostic procedure may help earlier disease identification.
Link: https://www.ncbi.nlm.nih.gov/pubmed/29740872

Titel: Five years before multiple sclerosis onset: Phenotyping the prodrome.
Conclusion: Phenotyping the prodrome 5 years before clinical recognition of MS is feasible.
Link: https://www.ncbi.nlm.nih.gov/pubmed/29979093

Titel: Prodrome in relapsing‐remitting and primary progressive multiple sclerosis
Conclusion: Findings suggest that people with RMS and PPMS may both experience a prodrome, although aspects may differ.
Link: https://onlinelibrary.wiley.com/doi/abs/10.1111/ene.13925

Titel: Mining healthcare data for markers of the multiple sclerosis prodrome
Conclusions: Findings provide insight into the clinical characteristics of the MS prodrome. Diagnostic codes from physician encounters were capable of differentiating between MS cases and controls.
Link: https://www.msard-journal.com/article/S2211-0348(18)30274-8/fulltext